Ozonated Glycerin — nasal spray

Ozonated glycerin is one of the newest formats in ozone skincare, and one of the least understood. This guide exists to fix that. It covers what ozonated glycerin is, how it differs chemically from ozonated oils, what the published research does and doesn't show, and how to use it in a daily routine.

We make Glyzine(TM), our ozonated glycerin, at a stated concentration of approximately 10,000 ppm from USP-grade organic vegetable glycerin in an ISO Class 5 cleanroom environment. It is, as far as we know, the first ozonated glycerin backed by an independent LC-MS chemical profile, and we publish what that analysis can and cannot tell us. The science on this ingredient is early - a small number of controlled cosmetic studies and a growing body of laboratory work - and these articles say so plainly.

Start with "What Is Ozonated Glycerin" if you're new, or the chemical profile if you want the chemistry first.

1 article

How to Use Ozonated Glycerin: Nasal Spray, Drinking, Nebulizing and Skin

How much ozonated glycerin to use and what to mix it with: about 10% in saline for a nasal spray, ½ teaspoon to 1 tablespoon a day to drink, 2.5% to 10% to nebulize, and 10% in ...

Nattha Wannissorn, PhD · Updated October 2026

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Disclaimer: Simply O3 ozone equipment is sold for general and precise ozone production. Our ozonated skincare products are intended for cosmetic use, and our ingestible products are dietary supplements. They are not medical products, and no product or statement on this website is intended to diagnose, treat, cure, or prevent any disease or health condition. Statements on this website have not been evaluated by the Food and Drug Administration. Testimonials reflect individual experiences and are not a guarantee of results. Information on this site is provided for educational purposes and is not a substitute for guidance from a qualified professional.