Ozone oil massage therapy - benefits, risks, and what to look for

Ozone oil massage therapy - benefits, risks, and what to look for

Are you looking to enhance the health benefits of your massage therapy sessions?

Aside from helping with oral health through oil pulling, topical ozone oil can also deliver benefits beyond the skin, such as relieving muscle soreness and aiding in exercise recovery. In this article, we’ll discuss how ozone oil delivers such benefits and synergizes with other ingredients in our ozone oil joint and muscle spray.

How does ozone oil massage therapy work?

To produce ozone oil, we bubble ozone gas through olive oil in a temperature-controlled reactor for up to 10 days. This process creates ozonides, which can break down into smaller molecules such as oxygen, peroxides, and lipid peroxidation products.

A clinical trial using ozone sauna in young men suggests that:

  • Lipid peroxidation byproducts can get absorbed through the skin barrier into the bloodstream. However, ozone gas, oxygen gas, and larger molecules from ozone exposure on the skin do not cross the skin barrier.
  • Temporarily increases blood oxygen and oxidative stress markers

While ozone oil massage therapy or topical ozone oil are not the same as ozone sauna, these results likely explain how ozone oil massage helps with tight muscles and joint discomfort.

Which ozone oil to use for ozone massage therapy and discomfort relief

To reap the most benefits from topical ozone oil and prevent side effects, the ozone massage oil should be:

  • Free from dangerous formaldehyde that tends to form from oil ozonation without temperature control
  • At the right peroxide levels–too much peroxide can irritate the skin. The ozone oil has to be diluted for this purpose. For our ozone joint and muscle spray, we standardize it to 1,200.
  • Mixed with a skin-safe cosmetic-grade skin penetration enhancer, such as ethanol, to enhance the absorption of beneficial LOPs through the skin

The ozonation process tends to destroy any and all polyphenols in the olive oil. However, once the oil has stable levels of peroxides, additional ingredients such as cannabidiol (CBD), skin penetration enhancers, and essential oils can be mixed in.

This led us to formulate our ozone muscles and joints spray, with the right concentration of:

  • Ozone oil, standardized for peroxide levels
  • Ethanol, for cooling effects and skin absorption enhancement
  • Isopropyl myristate, another cosmetic-grade skin absorption enhancer
  • Cannabidiol, for mood-enhancing, discomfort-relieving, and overall mind and muscle relaxation benefits
  • Hemp seed oil, for beneficial fatty acids
  • Camphor, for discomfort-relieving cooling effects
  • Menthol, for discomfort-relieving cooling and muscle relaxation benefits

Health benefits of ozone oil massage therapy

1. Improve circulation and tissue oxygenation

Most discomfort-relieving treatments such as massage therapy and physical therapy work partly by increasing blood flow and tissue oxygenation. By delivering lipid peroxidation products through the skin, topical ozone oil or ozone oil massage can:

  • Generate small amounts of oxidative stress that turn on antioxidant genes
  • Increase oxygen in tissues
  • Improve blood flow into and out of the area, which both increases nutrient and oxygen delivery, and waste removal from the area

These benefits synergize greatly with:

  • Massaging, rubbing, or other kinds of manual therapy treatments
  • Blood vessel-relaxing ingredients such as CBD, camphor, and menthol

This increase in circulation allows for greater delivery of oxygen and nutrients to localized areas. Also, the increased oxygen and the activation of your own antioxidant genes improve mitochondrial function, which tends to be stagnant with less blood flow. Improved mitochondrial activity means more cellular energy (ATP) for tissue recovery.

2. Help with exercise recovery and muscle fatigue

Intense exercise can increase lactic acid and other metabolic waste buildup in muscle, causing soreness, fatigue, and discomfort. To improve recovery from exercise, you’ll need proper blood flow, mitochondrial function, and oxygen to clear the metabolic waste. By increasing blood flow and boosting mitochondrial function, ozone oil massage can improve exercise recovery. It’s unclear whether LOPs can help break down lactic acid, even though ozone can oxidize lactic acid, helping to manage post-exercise discomfort and tenderness.

The exercise recovery benefits of ozone oil massage synergize with other ingredients, such as CBD. Topical CBD works with the body's endocannabinoid system (ECS) through specific cannabinoid receptors on the skin. It also works on the immune system to resolve minor muscle damages due to exercise.

3. Improving range of motion

Muscle tightness and stiffness, swelling, fascia adhesion, joint mechanical issues, and general lack of movement can limit the range of motion. Usually, movement despite the stiffness will improve recovery and help bring blood flow to the area. Depending on the root cause that limits the range, ozone oil massage may help.

In the literature, the application of ozone to joints seems to improve the range of motion and support joint health. Therefore, the application of ozone oil to the joint area may provide some of the similar effects.

Massage with topical ozonated oil can improve range of motion by:

  • Releasing growth factors that support tissue repair
  • Slowing the breakdown of joint tissue by promoting remodeling
  • Limiting swelling

4. Relieve tightness and may break adhesion

Muscles can tighten up into knots due to intense exercise, poor posture, dehydration, postural imbalances, and more. Releasing tight muscles through deep tissue massage can often be uncomfortable.

In a rat study, the application of ozone seems to break down and limit fascial adhesion. This suggests that topical ozone oil massage may have similar results, by increasing blood flow into the tight area and helping break down the adhesion.

5. Relief of muscle and joint discomfort

As mentioned above, topical ozone oil can synergize with massage and other ingredients to help with muscle and joint discomfort by:

  • Increasing blood flow into the area
  • Supporting the breakdown of lactic acid and other cellular waste due to muscle fatigue
  • Supporting a balanced inflammatory and antioxidant response
  • Relieving muscle tightness and may break fascial adhesion that limit range of motion
  • Improving range of motion
  • Supporting a relaxation response, improving serotonin and endorphins
  • Acting on nerve endings

Ozone massage can become even more powerful relief when combined with ingredients such as:

  • CBD, which works on the immune system and the skin’s endocannabinoid system
  • Camphor and menthol, which have soothing cooling effects

6. Improve skin health

Ozonated oil for the specific use of skin health is gaining popularity and research. This ingredient can address many concerns. Along with added ingredients such as CBD and tocopherol (vitamin E), included in the Simply O3 ozone oil + CBD spray, this product has a well-rounded approach to skin health.

The lipid peroxide and ozonides in ozone oil can deliver a small amount of oxidative stress that activates anti-aging and regenerative pathways in the skin.

Vitamin E (tocopherol) is an additional ingredient in Simply O3 ozone oil + CBD spray. Vitamin E is a common fat-soluble antioxidant in skincare, specifically in healing scars and wounds. Typically taken as an oral supplement, but topically has the ability to change how the body produces collagen and glycosaminoglycans in the skin. Glycosaminoglycans are important long chains of sugars that play a role in the structure and function of tissues such as skin, cartilage, and connective tissue.

The overall list of benefits for skin health is extensive, and scientists are still exploring this topic. Although the Simply O3 ozone oil + CBD spray can used for muscle recovery and discomfort, the additional skin health benefits are an added bonus.

How to choose an ozone massage oil


The purity of an ozonated massage oil is important, as many things included in a fat-soluble form can be absorbed through the skin barrier [10].

To ensure purity, a product should use cold production. Cold production of ozonated oil is when ozone gas (O3) bubbles through a carrier oil until saturation at low temperatures. This ensures quality and potency and limits any by-products like formaldehyde, which is dangerous. After production, ozonated oil must be stored in a dark and cool place [11]

Secondly, an ozonated oil should be free from formaldehyde and other toxic byproducts [12]. Our internal testing process confirms that our ozone oil is free from formaldehyde that can be inflammatory. 

Standardized peroxide levels

To give an oil the term “ozonated,” the amount of peroxides should be quantified to measure the oil's capacity to deliver oxygen [12]. Simply O3 oil + CBD spray has a standardized peroxide level of 1,200 so you can be confident in the potency.

Peroxide levels are also measured to evaluate stability in an ozonated oil [12]. The peroxide value indicates the amount of peroxide in the ozonated oil and is expressed as the active oxygen amount per kilogram of sample (mmol-meq/kg) [12]

Ozonated olive oil has advantages over other vegetable oils as it’s highly stable and can maintain a relatively stable peroxide number for up to 2 years.


Ozonated oil can be a great addition to your selfcare routine. Simply O3 ozone joint and muscle spray can support exercise recoveries, improve circulation, relieve joint discomfort, and more. 

When choosing an ozone oil massage therapy product, look for cold-processed, free from aldehydes, and with standardized peroxide levels, such as Simply O3 ozonated oil + CBD spray. 

As instructed: spray the oil onto the affected area up to 3x per day. 

We have a 30-day money-back guarantee. If you are not satisfied with the product, let us know and ship it back, even if it's opened, for a full refund minus shipping costs. 

1 Bocci, V., Borrelli, E., Valacchi, G. and Luzzi, E. (1999) Quasi-total-body exposure to an oxygen-ozone mixture in a sauna cabin. Eur. J. Appl. Physiol. Occup. Physiol. 80, 549–554
2 Park, J., Kim, J. and Mikami, T. (2021) Exercise-Induced Lactate Release Mediates Mitochondrial Biogenesis in the Hippocampus of Mice via Monocarboxylate Transporters. Front. Physiol. 12, 736905
3 Elhamid, H. (2021) Therapeutic Effect of Ozone in the Treatment of Chronic Non Specific Low Back Pain. American Journal of Preventive Medicine and Public Health, American Journal of Preventive Medicine and Public Health 7
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7 Kaada, B. and Torsteinbø, O. (1989) Increase of plasma beta-endorphins in connective tissue massage. Gen. Pharmacol. 20, 487–489
8 Anzolin, A. P., da Silveira-Kaross, N. L. and Bertol, C. D. (2020) Ozonated oil in wound healing: what has already been proven? Med. Gas Res. 10, 54–59
9 Keen, M. A. and Hassan, I. (2016) Vitamin E in dermatology. Indian Dermatol. Online J. 7, 311–315
10 Oliveira Modena, D. A., de Castro Ferreira, R., Froes, P. M. and Rocha, K. C. (2022) Ozone Therapy for Dermatological Conditions: A Systematic Review. J. Clin. Aesthet. Dermatol. 15, 65–73
11 Radzimierska-Kaźmierczak, M., Śmigielski, K., Sikora, M., Nowak, A., Plucińska, A., Kunicka-Styczyńska, A., et al. (2021) Olive Oil with Ozone-Modified Properties and Its Application. Molecules 26 https://doi.org/10.3390/molecules26113074
12 Ugazio, E., Tullio, V., Binello, A., Tagliapietra, S. and Dosio, F. (2020) Ozonated Oils as Antimicrobial Systems in Topical Applications. Their Characterization, Current Applications, and Advances in Improved Delivery Techniques. Molecules 25 https://doi.org/10.3390/molecules25020334

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