Ozone oil has demonstrated regenerative and soothing benefits, but it tastes and smells unappetizing. Ozone oil capsules make it possible to get similar benefits in the digestive system. Recently, we’ve made available the Stomach Caps and Intesti Caps, which deliver ozone oil benefits in the stomach and upper intestine, respectively. This article explains the unique benefits and specific uses for each type of ozone oil capsules.
SimplyO3 Regular Ozone Oil Capsules Vs. Stomach Caps Vs. Intesti Caps – What Are They?
Food-grade ozone oil capsules make it possible to ingest ozone oil without tasting or smelling the oil. Currently, we have three different types of ozone oil capsules, including:
-
Regular ozone oil capsules, each providing 500 mg of 600 PV organic ozonated olive oil in a cellulose capsule.
-
Stomach Caps, with acid-resistant capsules and bioadhesive technology that helps ingredients stick to the stomach lining. Each 4-capsule serving provides 130 mg of 600 PV ozonated olive oil along with stomach soothing ingredients, including zinc citrate, L-carnosine, vitamin A, and molybdenum.
-
Intesti Caps, with acid-resistant capsules that open in the duodenum, targeted for the small intestine. Each 3-capsule serving provides 112.5 mg of 600 PV ozonated olive oil along with intestinal and mucosal barrier support ingredients, including vitamin B6, vitamin D, and vitamin K.
What To Keep In Mind When Buying Ozone Oil
Many commercial ozone oils out there are ozonated in uncontrolled environments, which can produce formaldehyde, nitrogen compounds, or other contaminants. Whereas, at SimplyO3, our ozone oil chemists who formulate and manufacture the oils also study the chemistry and health benefits of the oils. The oils are ozonated in proprietary controlled cold reactors, with pure oxygen-ozone gas, so you can be sure that the ozone oil is pure and safe for consumption. We also standardize the peroxide value according to the European pharmacological standards, with potency lasting 3 years without refrigeration.
Why SimplyO3 Stomach Caps?
Many people look to ozone oils to reoptimize their gut lining when their practitioner says they may have intestinal permeability. Regular ozone oil capsules open in the digestive tract, delivering ozonides that may react with stomach acid, potentially producing hydrogen peroxide or other byproducts in the gut content. This works for some people, but can create stomach discomfort for others. This is why we designed Stomach Caps specifically for the stomach lining.
By protecting the content from stomach acid and slowly releasing it, we minimize the amount of ozonides that react with stomach acid and hydrogen peroxide created in the stomach content. It also provides a small amount of oxidative stress over time, minimizing potential discomfort. The ozonides in the ozone oil can stimulate Nrf2 signaling pathways in the stomach lining, which then activates various antioxidant, regenerative, and rebalancing pathways. The small amount of oxidative stress may also activate local immune cells.
Zinc, L-carnosine, molybdenum, and vitamin A provide cofactors to antioxidant enzymes. They also soothe and support the stomach lining’s natural repair in parallel with the ozone oil’s oxidative and regenerative effects.
Stomach Caps Ingredients
L-Carnosine (40 mg)
L-carnosine is a dipeptide composed of beta-alanine and histidine. Naturally, your stomach tissues have a lot of zinc and carnosine compared to other tissues. Preclinical studies suggest that it supports mucosal healing and modulates immune response.
Its buffering capacity and ability to chelate reactive carbonyl compounds suggest a protective role under conditions of oxidative or acid-induced stress [1].
Zinc (20 mg as Zinc Citrate)
Zinc is an essential trace element, and contributes to epithelial integrity and immune surveillance. It’s a key cofactors for the readouts of genes that encode tight junction proteins and regeneration of the stomach mucosal barrier [2]. Many people with occasional stomach issues are also deficient in zinc.
Zinc has a synergistic effect with L-carnosine to protect the stomach lining [1].
Vitamin A (1500 mcg RAE as Retinyl Acetate)
Vitamin A is a key vitamin for many gene readouts that help maintain the gut lining and help it self-repair from day-to-day exposures [3].
Molybdenum (200 mcg as Sodium Molybdate Dihydrate)
Molybdenum is less frequently discussed in gastrointestinal health, but serves as a cofactor for enzymes involved in sulfur metabolism and aldehyde detoxification [4].
Its presence may support the breakdown of metabolic byproducts and oxidative intermediates in the stomach [4].
SimplyO3 Stomach Caps help with stomach homeostasis by slowly delivering ozonides on the mucosal lining along with micronutrients that support mucosal resilience.
How to take: Start with one capsule in the morning and one at night. If no irritation occurs, increase the dose to two capsules in the morning and two at night, 20 minutes before eating.
If you’re consuming other foods or supplements high in vitamin A (retinol), consider cycling off the StomachCaps every third month. During this month, use Organic Ozone Oil Capsules as needed.
Why Intesti Caps
Many people use ozone oil to optimize the intestinal barrier or terrain, but may struggle with the discomfort from taking regular ozone oil. Also, some ozonides react with stomach acid, creating hydrogen peroxides and other byproducts, and leaving little for the intestines. Therefore, we formulated Intesti Caps with acid-protective capsules that deliver in the small intestine where it may modulate the local flora and stimulate Nrf2-mediated processes.
Accompanying the ozonated oil is a triad of essential vitamins: Vitamin B6, Vitamin D3, and Vitamin K2 (as menaquinone-7), each of which has a targeted physiological role in the intestinal mucosal barrier.
Intesti Caps Ingredients
Vitamin B6 (Pyridoxine Hydrochloride)
Vitamin B6 is involved in the synthesis of neurotransmitters such as serotonin and GABA, which influence the gut-brain axis [5].
It also plays a role in modulating immune responses, which are particularly relevant in the context of intestinal homeostasis.
Deficiencies in B6 have been associated with shifts in microbial composition and decreased mucosal immunity [6]. Many people with suboptimal intestinal health are deficient in vitamin B6 [7].
Vitamin D3 (Cholecalciferol)
Vitamin D modulates immune balance and function.
In the gastrointestinal tract, Vitamin D helps maintain tight junctions between epithelial cells. Low levels of vitamin D correlates with increased intestinal permeability and imbalanced gut flora [8].
Vitamin K2 (Menaquinone-7)
Although K2 is more commonly recognized for its role in calcium metabolism, it may also contribute to mucosal tissue health through its immune-modulating and vascular-stabilizing properties.
Research suggests that it works with vitamin D3 to help maintain the gut lining and immune balance [9].
SimplyO3 Intesti Caps are not a treatment for any specific condition, but rather a tool to support a balanced and resilient intestinal terrain and mucosal lining health.
How to take: Take one capsule three times a day before meals.
SimplyO3 Ozone Olive Oil Capsule Vs. Stomach Caps Vs. Intesti Caps Comparison
|
Product |
|||
|
Ideal for |
Gut and possibly some other benefits |
The stomach |
Small intestine |
|
Key ingredients |
Ozonated organic olive oil |
Ozonated organic olive oil, L-carnosine, zinc, vitamin A, molybdenum |
Ozonated organic olive oil; vitamins B6, D, K |
|
Where it delivers ozonides |
Stomach chamber and stomach content |
Stomach lining; slowly released |
Intestine |
|
Benefits |
Delivers ozonides that may oxidize, soothe, and support regenerative processes |
Coats, calms, and supports stomach mucosal barrier homeostasis |
Supports small intestinal barrier terrain and intestinal integrity |
|
Long-term use safety |
Should only be used a few months to avoid excess acidity |
May need to be cycled off every third month if other vitamin A foods or supplements are also used |
Safe for long-term use without negative effects |
1 Efthymakis, K. and Matteo, N. (2022) The role of Zinc L-Carnosine in the prevention and treatment of gastrointestinal mucosal in humans: A review. Clinics and Research in Hepatology and Gastroenterology, Elsevier Masson 46, 101954
2 Ohashi, W. and Fukada, T. (2019) Contribution of zinc and zinc transporters. J Immunol Res 2019, 8396878
3 Iyer, N. and Vaishnava, S. (2019) Vitamin A at the interface of host-commensal interactions. PLoS Pathog 15, e1007750
4 Adamus, J. P., Ruszczyńska, A. and Wyczałkowska-Tomasik, A. (2024) Molybdenum’s role as an essential element in enzymes catabolizing redox reactions: A review. Biomolecules 14
5 Qing, W., Chen, H., Ma, X., Chen, J., Le, Y., Chen, H., et al. (2025) Gut dysbiosis-induced vitamin B6 contributes to chronic stress-related abnormal behaviors in a cortisol-independent manner. Gut Microbes 17, 2447824
6 Wan, Z., Zheng, J., Zhu, Z., Sang, L., Zhu, J., Luo, S., et al. (2022) Intermediate role of gut microbiota in vitamin B nutrition and its influences on human health. Front. Nutr., Frontiers 9, 1031502
7 Ligaarden, S. C. and Farup, P. G. (2011) Low intake of vitamin B6 is associated with symptoms. Nutrition Research, Elsevier 31, 356–361
8 Akimbekov, N. S., Digel, I., Sherelkhan, D. K., Lutfor, A. B. and Razzaque, M. S. (2020) Vitamin D and the host-gut microbiome: A brief overview. Acta Histochem Cytochem 53, 33–42
9 Lai, Y., Masatoshi, H., Ma, Y., Guo, Y. and Zhang, B. (2021) Role of Vitamin K in intestinal health. Front Immunol 12, 791565
