What Is Ozonated Glycerin?
Ozonated glycerin—also called ozonized glycerin—is glycerin that has been saturated with ozone gas under controlled conditions. The result is a stable, water-soluble compound that carries ozone chemistry in a format fundamentally different from ozonated oils: it absorbs cleanly into skin, leaves no greasy residue, and has no ozone odor.
Glycerin itself is a humectant—it draws moisture toward the skin rather than sitting on top of it. When ozonated, it combines that hydrating action with the active chemistry of ozone in a format that works as a standalone moisturizer, a serum layer, or a base in a broader ozone skincare routine.
How SimplyO3 Makes Glyzine™
SimplyO3 Glyzine™ is produced at approximately 10,000 ppm—a stated potency that, as of this writing, no other ozonated glycerin brand publishes. It is made from USP-grade organic vegetable glycerin, saturated with pure oxygen-fed ozone in a sealed system, and manufactured in a cleanroom environment built to ISO Class 5 specifications. Each batch is made to order and ships within two business days of production.
Potency is a function of ozone gas concentration, flow rate, and glycerin volume—not simply duration. The result is what matters: a consistently saturated product at a stated, verifiable concentration.
Ozonated Glycerin vs. Ozonated Oil: What's the Difference?
These are complementary formats, not interchangeable ones. The key differences:
- Base: Glycerin is water-soluble; ozonated oils are lipid-based
- Texture: Glyzine absorbs quickly with no grease; ozonated oils are thicker and more occlusive
- Odor: Glyzine has no ozone smell; ozonated oils carry a characteristic scent
- Use case: Glyzine is suited for daily hydration, daytime use, and layering; ozonated oil is suited for targeted, heavy-duty, or overnight application
- Skin type: Glyzine works well for oily and combination skin; ozonated oil is preferred for dry skin or intensive use
Many users incorporate both: Glyzine as a daily base layer, ozonated olive oil as an evening or targeted application.
What Does the Research Show?
The science on ozonated glycerin applied to skin is early-stage. The strongest available evidence includes:
- A 2022 controlled study (Shiota, Valacchi et al., Journal of Cosmetic Dermatology) in which ozonized glycerin formulations applied to facial age spots for eight weeks.
This is an emerging ingredient category.
How to Use Ozonated Glycerin
Glyzine™ is versatile enough for most routines:
- As a daily moisturizer: Apply a pea-sized amount to clean, slightly damp skin. Absorbs in 30–60 seconds.
- As a serum layer: Apply after cleansing, before SPF or heavier products. Layers cleanly without pilling.
- As a spot application: Apply directly to areas of uneven tone, rough texture, or dryness.
- As an evening base: Apply Glyzine first, then layer ozonated olive oil on top for sustained overnight contact.
A note on the absence of odor: Glyzine has no ozone smell. This is a property of the glycerin base, not an indicator of lower potency. The product is saturated at ~10,000 ppm regardless.
