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Ozone is powerful but impatient. As a gas, it loses potency in minutes. In water, it's gone within an hour.
That's why many people choose ozonated olive oil, but glycerin does something oil can't: it dissolves in water.
Glycerin is the backbone of most fats in your body, yet it's water-soluble — allowing it to carry ozone into places oil can't reach.



Glyzine is highly concentrated, so a little goes a long way. Start with a small amount and adjust based on how your skin responds.
Apply topically: Place a small amount on your fingertips and apply a thin layer to clean skin as needed. Glycerin is naturally hydrating and absorbs gradually without greasy residue.
Mix with other products: Glyzine can be diluted into lotions, creams, or serums without affecting its stability. Many users add just a few drops to their existing products.


Glyzine is a clear to faintly golden gel — thicker than water, but it spreads easily and absorbs into the skin without leaving behind an oily residue.
It has the natural, mildly sweet character that glycerin is known for, with no added fragrance or scent.

Glyzine contains a single ingredient: ozonated organic glycerin.
Our glycerin is food-grade and laboratory-grade, derived from edible plant fats — never petroleum. Petroleum-derived glycerin can carry contaminants that create formaldehyde and toxic peroxides when ozonated.
Starting with 100% pure glycerin ensures clean, beneficial peroxides with zero harmful byproducts.
We ozonate our glycerin in a sealed, controlled environment free of room air. Only pure oxygen and ozone.
Why does this matter? The air you breathe is roughly 80% nitrogen. When ozone reacts with nitrogen in room air, it creates unwanted contaminants.
Home ozonation can't avoid this issue, even with a medical-grade generator. Neither can facilities that ozonate in open air. Our sealed system eliminates nitrogen contamination entirely, ensuring you get pure ozonated glycerin with nothing else mixed in.


Glyzine is produced daily in small batches using a touchless, automated system in a clean room built to ISO Class 5 guidelines — the same standard required for surgical implants. Yes, it's probably overkill, but that's just how we do things.
Every bottle is filled, capped, and labeled without human contact, then ships within 2 business days of bottling. No warehouse inventory. No months-old stock.
By bottling fresh daily and shipping within 2 business days, you receive Glyzine at peak potency — not after months of degradation in storage.
No Fillers
No Carriers
No Fragrance
No Petroleum
No Preservatives
No Stabilizers
No Binders
No Gmos

Glyzine dissolves in water, giving you options oil-based products can't match:
The ozone remains stable regardless of how you incorporate it. Additional ingredients don't degrade its activity.
Our favorite testimonials pulled from our verified product reviews below
“OG stands for ’Oh Gosh’ this stuff is a miracle”
~ Mike T.
“This is the most dramatic skin product I have ever tried, even the really expensive lotions/potions.”
~ Kirstin B.
“Helps me look younger for sure”
~ Jeremiah T.
“Worked wonders on all of my itches. I love this stuff!”
~ Carrie-Anne M.
“The fountain of youth.”
~ Leslie
“Glyzine makes your skin look and feel amazing.”
~ Michael L.
“I mix it with my body lotion. I love the immediate change in my skin.”
~ Gabriela R.
“It has helped me in so many instances.”
~ Alina
It depends on how often you use it and how many people (or pets) are using it. A 2oz bottle typically lasts one person 1 month. Since Glyzine is highly concentrated, a little goes a long way.
Glycerin is generally well-tolerated, but we recommend doing a patch test first. Start with a very small amount on a small area of skin and wait 24 hours to see how your skin responds. Since Glyzine is water-soluble, you can also dilute it with water if you want to reduce the concentration. Many users also dilute Glyzine into lotions, creams, or serums.
Ozonated glycerin slowly loses potency over time. Refrigeration significantly extends its shelf life and maintains peak effectiveness.
Unlike oils, Glyzine is water-soluble, which means it absorbs into skin rather than sitting on the surface. It also has no greasy residue or chemical smell, and you can mix it with both water-based and oil-based products.
Glyzine is intended for topical use only. We cannot provide guidance on internal use.
No. Unlike ozonated oils, Glyzine is water-soluble and won't stain fabrics.
Glyzine has a very mild, naturally sweet scent from the glycerin itself — no chemical or rancid oil smell.
Glyzine is significantly more concentrated than most ozonated glycerin products on the market. Research typically uses 80-800 ppm formulations, while Glyzine is ozonated closer to 10,000 ppm.
Yes. Many users dilute Glyzine into lotions, creams, or serums. Dilution does not affect ozone stability.

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Alexa answers the phone weekdays from 8:30am to 4:30pm Eastern
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DOWNLOAD GUIDE TO OZONEDisclaimer: Simply O3 clarifies that the products displayed on this website are not approved medical devices (unless otherwise stated). Governing health authorities do not support the use of ozone in medicine. Simply O3 LLC makes no claims nor suggestions regarding the use of ozone, oxygen, saunas, or ozone related products for ozone therapy for cancer or any other diseases or health challenges. Please consult a qualified physician before using any products, drugs, or devices that may affect your health. Statements made on this website have not been evaluated by the Food and Drug Administration.