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You don't need another 10-step routine. You don't need another ingredient list you can't pronounce.
You need skin that feels hydrated all day, looks smooth and calm without effort, and doesn't punish you for keeping it simple.
One mist. Morning and night. Skin that looks healthy, feels soft, and glows on its own. That's it. That's the whole promise.


Hyaluronic acid and Glyzine work together to draw moisture into your skin and lock it in. Clinical research shows hyaluronic acid significantly improves skin hydration by reducing water loss in the skin. You'll notice softer, more supple skin right away — and the effect builds over time.
Glyzine (ozonized glycerin) shares the skin-renewing properties of ozonated oils, promoting fibroblast activity and collagen production, but in a water-soluble form that absorbs clean. The science suggests it supports the natural processes that promote healthy skin.
Studies on hyaluronic acid and collagen peptides report improvements in skin elasticity, firmness, and the appearance of fine lines. Users often notice smoother texture and a more youthful look after consistent use.
Here are some of the ways people are using this spray:

This is our proprietary ingredient — an ultra-potent ozonated glycerin gel that delivers ozone to places oils simply can't reach.That's because our plant-based glycerin is water-soluble, so your cells can soak it up. It absorbs clean, feels light, and lets your skin do what it does best.
Nature's moisture magnet, hyaluronic acid can hold up to 1,000 times its weight in water. Clinical studies show it improves skin hydration, reduces the appearance of fine lines, and supports skin elasticity. You'll feel the plumping effect almost immediately.
These are tiny fragments of collagen protein that can penetrate the skin's surface. Research suggests collagen peptides support skin elasticity and smoothness, helping maintain that firm, youthful texture we all want.
A soothing, conditioning ingredient that helps strengthen your skin's moisture barrier. Panthenol calms irritation and supports hydration and it's gentle enough for sensitive skin.
Pure aloe vera juice straight from the plant. Aloe has been used for centuries to soothe and hydrate skin with its natural plant compounds. It's cooling, calming, and deeply moisturizing.
This is a natural, plant-derived preservative made from fermented radish root. We chose it because it keeps the formula fresh without synthetic chemicals. Clean preservation for clean skincare.
No Fillers
No Sulfates
No Fragrance
No Parabens
No GMOs
No Petroleum
| Glyzine + Peptide Spray | HA Serum | Collagen Cream | Hydrating Toner | |
|---|---|---|---|---|
| Immedidate Hydration | Excellent | Excellent | Good | Limited |
| Sustained Moisture | Excellent | Good | Good | Limited |
| Appearance of Fine Lines | Excellent | Good | Good | Limited |
| Elasticity Support | Excellent | Limited | Good | Limited |
| Barrier Support | Excellent | Good | Limited | Limited |
| Post-Facial Recovery | Excellent | Excellent | Limited | Limited |
| Clean Ingredient Profile | Excellent | Good | Good | Limited |
| Non-Comedogenic | Excellent | Good | Limited | Good |
| Full-Spectrum Skin Support | Excellent | Limited | Limited | Limited |

Morning
After cleansing, before moisturizer or makeup
Evening
After cleansing, before your nighttime routine
Anytime
Mid-day refresh, or whenever your skin feels dry
Every bottle of Glyzine + Peptide Spray is handmade in small batches inside a clean room built to ISO Class 7 (pharmaceutical-grade) guidelines, so your bottle arrives as fresh as possible. And every single ingredient in this formula scores a 1 on the EWG scale, the safest rating there is.
“Clean” isn't a marketing word for us. It's the standard.

With daily morning and evening use (2-3 sprays each time), one 3.4 fl oz (100ml) bottle typically lasts 4-6 weeks.
Yes. It's fragrance-free, made with gentle, plant-based ingredients, and free from parabens and sulfates. Always patch-test if you have very sensitive skin.
It has a very mild, clean scent from the natural ingredients — no synthetic fragrance added.
Absolutely. It layers beautifully under serums, moisturizers, and makeup. Use it as the first step after cleansing.
You'll feel immediate hydration and a plumping effect right after you spray it. For improvements in skin texture, fine lines, and elasticity, most people notice visible changes within 2-4 weeks of consistent daily use.
Not required, but recommended. Refrigeration extends the potency of the ingredients and feels amazing on your skin.
Regular glycerin is just a humectant. Glyzine is ozonized glycerin, which means it has the same skin-supporting properties as ozonized oils — research shows these promote hydration, skin renewal, and barrier support beyond basic moisture.
It's designed for facial use, but you can spray it anywhere you want light hydration — décolletage, hands, wherever.
180 days (about 6 months) after opening. Store it properly to maximize freshness.
Yes. We do not test on animals.
We offer a 30-day return policy. If you're not satisfied, you can return it within 30 days (even if opened). You're responsible for return shipping.

Call 844.655.2524
Alexa answers the phone weekdays from 8:30am to 4:30pm Eastern
After hours you can text that number or email her at info@simplyo3.com and she'll get back to you ASAP!
Still learning about Ozone?
DOWNLOAD GUIDE TO OZONENot sure if you have what it takes to use ozone equipment? Using an ozone generator is actually easier.
Not sure if you have what it takes to use ozone equipment?
DOWNLOAD GUIDE TO OZONEDisclaimer: Simply O3 clarifies that the products displayed on this website are not approved medical devices (unless otherwise stated). Governing health authorities do not support the use of ozone in medicine. Simply O3 LLC makes no claims nor suggestions regarding the use of ozone, oxygen, saunas, or ozone related products for ozone therapy for cancer or any other diseases or health challenges. Please consult a qualified physician before using any products, drugs, or devices that may affect your health. Statements made on this website have not been evaluated by the Food and Drug Administration.